cGMP kinase I, cardiac hypertrophy and PDE inhibition
نویسندگان
چکیده
Background The heart responds to maladaptive pro-hypertrophic stimuli by stimulating intrinsic signals that contrast and dampen the onset and development of hypertrophy. Cyclic guanosine monophosphate (cGMP) and its downstream effector cGMP kinase I (cGKI) have been suggested to be an important anti-hypertrophic signalling pathway (1). Intracellular levels of cGMP can be raised by the action of nitric oxide (NO) and natriuretic peptides (ANP, BNP), or by inhibiting cGMP-degrading phosphodiesterases (PDE).
منابع مشابه
Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II
Left ventricular hypertrophy leads to heart failure and represents a high risk leading to premature death. Cyclic nucleotides (cAMP and cGMP) play a major role in heart contractility and cyclic nucleotide phosphodiesterases (PDEs) are involved in different stages of advanced cardiac diseases. We have investigated their contributions in the very initial stages of left ventricular hypertrophy dev...
متن کاملReply to the Letter to the Editor
To the Editor roles of guanylyl cyclases must be viewed carefully. The reports [8,9] cited by Dr. Herring, et al. gave evidence We thank Dr. Herring et al. for their comments on our against the endothelial NO synthase hypothesis and NO in paper. In our recent report [1] we proposed that the muscarinic inhibition of I . Such experiments could not postjunctional source of cardiomyocyte cGMP, from...
متن کاملReply to the Letter to the
address completely the issue of guanylyl cyclase and soluble or particulate guanylyl cyclase, imposed direcmuscarinic inhibition. Moreover, we consider that recent tionality on the response to ligands. Such considerations investigations have strengthened rather than diminished the also apply to stimulation of L-type calcium current (I ) Ca(L) importance of cGMP signaling, per se and in connecti...
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BACKGROUND Cardiac hypertrophy is a major risk factor for morbidity and mortality in a number of cardiovascular diseases. Consequently, the signaling pathways that inhibit cardiac hypertrophy are currently receiving much interest. Among them, nitric oxide (NO), signaling via cGMP and cGMP-dependent protein kinase I, has been recognized as a negative regulator of cardiac hypertrophy. The present...
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Recent investigation has focused on identifying signaling pathways that inhibit cardiac hypertrophy, a major risk factor for cardiovascular morbidity and mortality. In this context, nitric oxide (NO), signaling via cGMP and cGMP-dependent protein kinase type I (PKG I), has been recognized as a negative regulator of cardiac myocyte (CM) hypertrophy. However, the underlying mechanisms are poorly ...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011